Is zolpidem the generic name for Ambien? I’m seeing conflicting information online and want to be absolutely sure. I understand Ambien is a prescription medication primarily used for insomnia. I’m interested in understanding if zolpidem is always interchangeable with Ambien, considering factors like dosage, release mechanisms (immediate release vs. extended release), and potential inactive ingredients. Are there circumstances where a doctor might specifically prescribe Ambien instead of generic zolpidem, or vice-versa, even if they both contain the same active ingredient, zolpidem? Finally, if zolpidem is the generic name, are there different manufacturers who produce zolpidem, and could there be subtle differences between these generic versions that might affect its efficacy or side effects?

Answer

Yes, zolpidem is the generic name for Ambien.

Zolpidem is a nonbenzodiazepine hypnotic medication used for the short-term treatment of insomnia. It works by binding to GABA receptors in the brain, similar to benzodiazepines, but with more selectivity for the α1 subunit. This selectivity is believed to contribute to its sedative effects with less of the anxiolytic, muscle-relaxant, and anticonvulsant effects associated with benzodiazepines.

Ambien was the original brand name for zolpidem, marketed by Sanofi-Aventis. After the patent for Ambien expired, other manufacturers began producing and selling zolpidem under its generic name.

Zolpidem is available in several forms, including immediate-release tablets, extended-release tablets (Ambien CR), and sublingual tablets (Edluar and Intermezzo). Different formulations have varying durations of action.

Common side effects of zolpidem can include drowsiness, dizziness, headache, nausea, and impaired coordination. More serious side effects, though less common, can include complex sleep-related behaviors such as sleepwalking, sleep-driving, and other activities performed while not fully awake. It carries warnings regarding next-day impairment, especially with the extended-release formulations.

Zolpidem, both as Ambien and its generic forms, is a Schedule IV controlled substance due to the potential for abuse and dependence.